Article
Altered Corticostriatal Connectivity and Exploration/Exploitation Imbalance Emerge as Intermediate Phenotypes for a Neonatal Dopamine Dysfunction.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2015
Braz Barbara Y, Galiñanes Gregorio L, Taravini Irene R E, Belforte Juan E, Murer M Gustavo
Abstract excerpt
Findings showing that neonatal lesions of the forebrain dopaminergic system in rodents lead to juvenile locomotor hyperactivity and learning deficits have been taken as evidence of face validity for the attention deficit hyperactivity disorder. However, the core cognitive and physiological intermediate phenotypes underlying this rodent syndrome remain unknown. Here we show that early postnatal dopaminergic...
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