Article
Deletion of dopamine D2 receptors from parvalbumin interneurons in mouse causes schizophrenia-like phenotypes.
Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2018
Tomasella Eugenia, Bechelli Lucila, Ogando Mora Belén, Mininni Camilo, Di Guilmi Mariano N, De Fino Fernanda, Zanutto Silvano, Elgoyhen Ana Belén, Marin-Burgin Antonia, Gelman Diego M
Abstract excerpt
Excessive dopamine neurotransmission underlies psychotic episodes as observed in patients with some types of bipolar disorder and schizophrenia. The dopaminergic hypothesis was postulated after the finding that antipsychotics were effective to halt increased dopamine tone. However, there is little evidence for dysfunction within the dopaminergic system itself. Alternatively, it has been proposed that excessive...
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