Article
Enhanced latent inhibition in dopamine receptor-deficient mice is sex-specific for the D1 but not D2 receptor subtype: implications for antipsychotic drug action.
The international journal of neuropsychopharmacology - 1 Apr 2009
Bay-Richter Cecilie, O'Tuathaigh Colm M P, O'Sullivan Gerard, Heery David M, Waddington John L, Moran Paula M
Abstract excerpt
Latent inhibition (LI) is reduced learning to a stimulus that has previously been experienced without consequence. It is an important model of abnormal allocation of salience to irrelevant information in patients with schizophrenia. In rodents LI is abolished by psychotomimetic drugs and in experimental conditions where LI is low in controls, its expression is enhanced by antipsychotic drugs with activity at...
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