Article

Structural Basis of Electron Transfer by the Human Nitric Oxide Synthase Holoenzyme Complex

2026-04-07

Abstract excerpt

Mammalian nitric oxide synthase (NOS) generates nitric oxide (NO), an essential signaling molecule in neurotransmission, inflammation, and cardiovascular regulation. NOS dysregulation contributes to neurodegeneration, septic shock, and ischemia. The structural basis of NOS function remains unclear, likely due to its dynamic, multi-component architecture. Catalysis requires electron transfer across five cofactors,...

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Literature Corpus work: d9ecc60f-71da-5ead-b4d8-c2c112d55a53
DOI: 10.64898/2026.04.06.716795

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