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Article

Domain interactions in neuronal nitric oxide synthase identified by time-resolved fluorescence.

Biophysical journal - 21 Apr 2026

Snyder Alexa A, McCoy Christian L, Gambill Alexandria K, Guadalupe Karina, Bailey Sheila K, Catlin Audrey E, Summers Steven B, Wynia-Smith Sarah L, Arnett David C, Smith Brian C, Johnson Carey K

Abstract excerpt

Nitric oxide synthase (NOS) catalyzes the formation of nitric oxide through the transfer of electrons from FAD to FMN in the reductase domain of the enzyme and then from FMN to a heme in the oxygenase domain of the partner enzyme in a homodimeric complex. The calcium-signaling protein calmodulin (CaM) binds to a CaM-binding domain located between the reductase and oxygenase domains to enable efficient NOS...

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Identifiers

PMID: 41830170
DOI: 10.1016/j.bpj.2026.03.022
PMCID: PMC13235957

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