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Article

Surface charges and regulation of FMN to heme electron transfer in nitric-oxide synthase.

The Journal of biological chemistry - 27 Aug 2010

Tejero Jesús, Hannibal Luciana, Mustovich Anthony, Stuehr Dennis J

Abstract excerpt

The nitric-oxide synthases (NOS, EC 1.14.13.39) are modular enzymes containing attached flavoprotein and heme (NOSoxy) domains. To generate nitric oxide (NO), the NOS FMN subdomain must interact with the NOSoxy domain to deliver electrons to the heme for O(2) activation during catalysis. The molecular basis and how the interaction is regulated is unclear. We explored the role of eight positively charged residues...

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Identifiers

PMID: 20592038
DOI: 10.1074/jbc.M110.138842
PMCID: PMC2930722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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