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Article

A cross-domain charge interaction governs the activity of NO synthase.

The Journal of biological chemistry - 23 Mar 2018

Haque Mohammad Mahfuzul, Tejero Jesús, Bayachou Mekki, Kenney Claire T, Stuehr Dennis J

Abstract excerpt

NO synthase (NOS) enzymes perform interdomain electron transfer reactions during catalysis that may rely on complementary charge interactions at domain-domain interfaces. Guided by our previous results and a computer-generated domain-docking model, we assessed the importance of cross-domain charge interactions in the FMN-to-heme electron transfer in neuronal NOS (nNOS). We reversed the charge of three residues...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29414777
DOI: 10.1074/jbc.RA117.000635
PMCID: PMC5868255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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