Article

The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation

2026-01-05

Abstract excerpt

MicroRNAs (miRNAs) associate with Argonaute (AGO) proteins to form complexes that down-regulate target RNAs, including mRNAs from most human genes 1–3 . Within each complex, the miRNA pairs to target mRNAs to specify their repression, and AGO provides effector function while also protecting the miRNA from cellular nucleases 2–5 . Although much has been learned about this mode of posttranscriptional gene regulati...

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Literature Corpus work: d9da0034-14e2-5033-bd14-5631a0075370
DOI: 10.64898/2026.01.05.697729

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