Article

JAK2 is highly expressed by cyst-lining cells and regulates cystogenesis

2018-08-02

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulated JAK/STAT signalling is implicated in polycystic kidney disease, which is a common genetic disease leading to renal failure. However, the mechanisms underlying JAK/STAT-mediated cystogenesis arepoorlyunderstood.TheroleofJAK2wasinvestigated immunohistochemically in a murine model of cystic disease (Pkd1 nl/nl ). In the normal kidney, JAK2 is restricted to tubular epithelial and vascu...

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Literature Corpus work: d9d8b60c-f6c9-5022-b460-3fb270806a9f
DOI: 10.1101/378919

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