Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Renal expression of JAK2 is high in polycystic kidney disease and its inhibition reduces cystogenesis

14 Mar 2019

Abstract excerpt

Abstract Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal genetic disorder, however it still lacks a cure. The discovery of new therapies heavily depends on understanding key signalling pathways that lead to ADPKD. The JAnus Kinase and Signal Transducers and Activators of Transcription (JAK/STAT) pathway is aberrantly activated and contributes to ADPKD pathogenesis via enhancing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomedical Research and Pathophysiology
Share to Genetic and Kidney Cyst Diseases
Share to Renal Diseases and Glomerulopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30872773
DOI: 10.1038/s41598-019-41106-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Renal expression of JAK2 is high in polycystic kidney disease and its inhibition reduces cystogenesisPMID 30872773Read ↗

JAK2 is highly expressed by cyst-lining cells and regulates cystogenesisSemantic proximity Read ↗

STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

<i>Ankhd1</i> enhances polycystic kidney disease development via promoting proliferation and fibrosisSemantic proximity Read ↗

Kidney: polycystic kidney diseaseSemantic proximity Read ↗

Molecular and cellular pathophysiology of autosomal recessive polycystic kidney disease (ARPKD).Semantic proximity Read ↗

Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin.Semantic proximity Read ↗

Polycystin-2 Regulates Proliferation and Branching Morphogenesis in Kidney Epithelial CellsSemantic proximity Read ↗

Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

Autosomal dominant polycystic kidney disease: Disrupted pathways and potential therapeutic interventions.Semantic proximity Read ↗

Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networksSemantic proximity Read ↗

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.Semantic proximity Read ↗

Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.