Article
High-Throughput Phenotypic Screening of Kinase Inhibitors to Identify Drug Targets for Polycystic Kidney Disease.
SLAS discovery : advancing life sciences R & D - 1 Sept 2017
Booij Tijmen H, Bange Hester, Leonhard Wouter N, Yan Kuan, Fokkelman Michiel, Kunnen Steven J, Dauwerse Johannes G, Qin Yu, van de Water Bob, van Westen Gerard J P, Peters Dorien J M, Price Leo S
Abstract excerpt
Polycystic kidney disease (PKD) is a prevalent disorder characterized by renal cysts that lead to kidney failure. Various signaling pathways have been targeted to stop disease progression, but most interventions still focus on alleviating PKD-associated symptoms. The mechanistic complexity of the disease, as well as the lack of functional in vitro assays for compound testing, has made drug discovery for PKD...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.