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Article

Fine-mapping causal tissues and genes at disease-associated loci.

Nature genetics - 1 Jan 2025

Strober Benjamin J, Zhang Martin Jinye, Amariuta Tiffany, Rossen Jordan, Price Alkes L

Abstract excerpt

Complex diseases often have distinct mechanisms spanning multiple tissues. We propose tissue-gene fine-mapping (TGFM), which infers the posterior inclusion probability (PIP) for each gene-tissue pair to mediate a disease locus by analyzing summary statistics and expression quantitative trait loci (eQTL) data; TGFM also assigns PIPs to non-mediated variants. TGFM accounts for co-regulation across genes and tissues...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 39747598
DOI: 10.1038/s41588-024-01994-2
PMCID: PMC12413687

Genes

PIP
SLC20A2
TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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