Article

Transcriptome-wide association studies: opportunities and challenges

2017-10-20

Abstract excerpt

Transcriptome-wide association studies (TWAS) integrate GWAS and gene expression datasets to find gene-trait associations. In this Perspective, we explore properties of TWAS as a potential approach to prioritize causal genes, using simulations and case studies of literature-curated candidate causal genes for schizophrenia, LDL cholesterol and Crohn’s disease. We explore risk loci where TWAS accurately prioritizes...

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Literature Corpus work: 466f57c4-6204-56c8-9661-c20047820442
DOI: 10.1101/206961

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