Article
A shared binding interface controls Vps13 organelle-specific targeting independently of its vacuolar protein sorting function.
Molecular biology of the cell - 1 Mar 2026
Jeffers Kevin Ryan, Dziurdzik Samantha Katarzyna, Davey Michael, Drotsky Jordan Faith, Conibear Elizabeth
Abstract excerpt
Yeast vacuolar protein sorting 13 (Vps13) is a bridge-like transporter that directs lipid flow between membranes at organelle contact sites. Vps13 targeting relies on organelle-specific adaptors containing proline-X-proline (PxP) motifs, which compete for binding to the Vps13 adaptor-binding (VAB) domain. Though a VAB-PxP interface has been identified for the mitochondrial adaptor Mcp1, whether other adaptors use...
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