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Article

Stairway to the Golgi: Two paths VPS13B can go by.

The Journal of cell biology - 2 Dec 2024

Pons Lanau Roger, Campelo Felix

Abstract excerpt

VPS13 proteins mediate lipid transfer across membranes. Among them, VPS13B is associated with Golgi membranes, and VPS13B mutations cause Cohen syndrome. In this issue, Ugur et al. (https://doi.org/10.1083/jcb.202311189) and Du et al. (https://doi.org/10.1083/jcb.202402083) reveal new VPS13B interactors and their functions in Golgi organization and trafficking.

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Source

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Identifiers

PMID: 39531071
DOI: 10.1083/jcb.202411005
PMCID: PMC11557495

Genes

VPS13B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stairway to the Golgi: Two paths VPS13B can go by.PMID 39531071Read ↗

VPS13B is localized at the interface between Golgi cisternae and is a functional partner of FAM177A1Semantic proximity Read ↗

VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1Semantic proximity Read ↗

Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport.Semantic proximity Read ↗

Sec23IP recruits VPS13B/COH1 to ER exit site–Golgi interface for tubular ERGIC formationSemantic proximity Read ↗

Sec23IP recruits the Cohen syndrome factor VPS13B/COH1 to ER exit site-Golgi interface for tubular ERGIC formationSemantic proximity Read ↗

Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease.Semantic proximity Read ↗

VPS13A and VPS13C influence lipid droplet abundanceSemantic proximity Read ↗

The Vps13 Family of Lipid Transporters and Its Role at Membrane Contact Sites.Semantic proximity Read ↗

Vps13 is required for the packaging of the ER into autophagosomes during ER-phagySemantic proximity Read ↗

Lysosome-Dependent Sphingolipid Regulation as a potential therapeutic Target for Cohen SyndromeSemantic proximity Read ↗

The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus.Semantic proximity Read ↗

In silico modeling human VPS13 proteins associated with donor and target membranes suggests lipid transfer mechanisms.Semantic proximity Read ↗

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