Article

Whole Genomes Define Concordance of Matched Primary, Xenograft, and Organoid Models of Pancreas Cancer

2017-10-30

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis among solid malignancies and improved therapeutic strategies are needed to improve outcomes. Patient-derived xenografts (PDX) and patient-derived organoids (PDO) serve as promising tools to identify new drugs with therapeutic potential in PDAC. For these preclinical disease models to be effective, they should both recapitulate the m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 49920f89-91b0-5b9b-876f-c8057e73cc92
DOI: 10.1101/209692

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Whole Genomes Define Concordance of Matched Primary, Xenograft, and Organoid Models of Pancreas CancerDOI 10.1101/209692Read

Whole genomes define concordance of matched primary, xenograft, and organoid models of pancreas cancerSemantic proximity Read

Pancreatic adenocarcinoma human organoids share structural and genetic features with primary tumorsSemantic proximity Read

Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data.Semantic proximity Read

Patient-derived Tumor Xenograft and Organoid Models Established from Resected Pancreatic, Duodenal and Biliary CancersSemantic proximity Read

The clone wars.Semantic proximity Read

Pancreatic cancer cell lines as patient-derived avatars: genetic characterisation and functional utility.Semantic proximity Read

Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma TumorsSemantic proximity Read

Patient-derived tumor xenograft and organoid models established from resected pancreatic, duodenal and biliary cancers.Semantic proximity Read

Deep molecular characterization linked to drug response profiling of pancreatic ductal adenocarcinoma using patient-derived organoidsSemantic proximity Read

Understanding pancreatic cancer genomesSemantic proximity Read

Challenges in genomic analysis of model systems and primary tumors of pancreatic ductal adenocarcinomaSemantic proximity Read

Tumor organoids improve mutation detection of pancreatic ductal adenocarcinoma.Semantic proximity Read