Article
A new genotoxicity assay based on p53 target gene induction.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Aug 2015
Zerdoumi Y, Kasper E, Soubigou F, Adriouch S, Bougeard G, Frebourg T, Flaman J-M
Abstract excerpt
The p53 tumor suppressor protein has emerged as a universal sensor of genotoxic stress that regulates the transcription of numerous genes required for appropriate cellular response to DNA damage. Therefore, transcriptional induction of p53 target genes can be considered as a global and early indicator of genotoxic stress. By performing expression microarrays and RNA-Seq analysis on wild-type and mutant TP53 human...
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