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Article

Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo.

Oncotarget - 22 Sept 2015

Tonelli Claudia, Morelli Marco J, Bianchi Salvatore, Rotta Luca, Capra Thelma, Sabò Arianna, Campaner Stefano, Amati Bruno

Abstract excerpt

The tumor suppressor p53 is a transcription factor that coordinates the cellular response to DNA damage. Here we provide an integrated analysis of p53 genomic occupancy and p53-dependent gene regulation in the splenic B and non-B cell compartments of mice exposed to whole-body ionizing radiation, providing insight into general principles of p53 activity in vivo. In unstressed conditions, p53 bound few genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26372730
DOI: 10.18632/oncotarget.5232
PMCID: PMC4694782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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