Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils.

doi:10.1016/j.stem.2023.05.004

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Article

Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils.

Cell stem cell - 1 Jun 2023

Huerga Encabo Hector, Aramburu Iker Valle, Garcia-Albornoz Manuel, Piganeau Marion, Wood Henry, Song Anna, Ferrelli Alessandra, Sharma Aneesh, Minutti Carlos M, Domart Marie-Charlotte, Papazoglou Despoina, Gurashi Kristian, Llorian Sopena Miriam, Goldstone Robert, Fallesen Todd, Wang Qian, Ariza-McNaughton Linda, Wiseman Daniel H, Batta Kiran, Gupta Rajeev, Papayannopoulos Venizelos, Bonnet Dominique

Abstract excerpt

Somatic mutations commonly occur in hematopoietic stem cells (HSCs). Some mutant clones outgrow through clonal hematopoiesis (CH) and produce mutated immune progenies shaping host immunity. Individuals with CH are asymptomatic but have an increased risk of developing leukemia, cardiovascular and pulmonary inflammatory diseases, and severe infections. Using genetic engineering of human HSCs (hHSCs) and...

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PMID: 37267914
DOI: 10.1016/j.stem.2023.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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