Article

Tafazzin regulates neutrophil maturation and inflammatory response

2024-06-05

Abstract excerpt

<h4>ABSTRACT</h4> Barth syndrome (BTHS) is a rare genetic disease caused by mutations in the TAFAZZIN gene. It is characterized by neutropenia, cardiomyopathy and skeletal myopathy. Neutropenia in BTHS is associated with life-threatening infections, yet there is little understanding of the molecular and physiological causes of this phenomenon. We combined bone marrow analysis, CRISPR/Cas9 genome editing in hematop...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bec89586-6768-5043-8c13-e112c577765f
DOI: 10.1101/2024.06.05.24307331

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tafazzin regulates neutrophil maturation and inflammatory responseDOI 10.1101/2024.06.05.24307331Read

Tafazzin regulates neutrophil maturation and inflammatory responseSemantic proximity Read

Advances in the understanding of Barth syndrome.Semantic proximity Read

A new murine model of Barth syndrome neutropenia links TAFAZZIN deficiency to increased ER stress-induced apoptosisSemantic proximity Read

Barth syndrome.Semantic proximity Read

Congenital neutropeniaSemantic proximity Read

Tafazzin-Deficient Zebrafish Display Mitochondrial Dysfunction, Neutropenia, and Metabolic Defects Without MyopathySemantic proximity Read

Pathogenic mechanisms and clinical implications of congenital neutropenia syndromesSemantic proximity Read

Clinical presentation and natural history of Barth Syndrome: An overview.Semantic proximity Read

<i>GATA1</i> knockout in human pluripotent stem cells generates enhanced neutrophils to investigate extracellular trap formationSemantic proximity Read

The Molecular and Genetic Mechanisms of Inherited Bone Marrow Failure Syndromes: The Role of Inflammatory Cytokines in Their PathogenesisSemantic proximity Read

<i>GATA1</i> Knockout in Human Pluripotent Stem Cells Generates Enhanced Neutrophils to Investigate Extracellular Trap FormationSemantic proximity Read

Lessons from congenital neutropenia: 50 years of progress in understanding myelopoiesisSemantic proximity Read