Article

Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in <i>UGGT1</i> knock-out mammalian cells

2023-05-31

Abstract excerpt

Endoplasmic reticulum (ER) retention of mis-folded glycoproteins is mediated by the ER- localised eukaryotic glycoprotein secretion checkpoint, UDP-glucose glycoprotein glucosyl-transferase (UGGT). The enzyme recognises a mis-folded glycoprotein and flags it for ER retention by reglucosylating one of its N-linked glycans. In the background of a congenital mutation in a secreted glycoprotein gene, UGGT-mediated ER...

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Literature Corpus work: c763a2b8-6bf2-5703-9dc0-40debd5400fc
DOI: 10.1101/2023.05.30.542711

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