Article

Structure and mechanism of the human TMEM260 O-mannosyltransferase

2026-03-17

Abstract excerpt

Protein O-linked mannose (O-Man) glycosylation is essential for mammalian development, and mutations in its biosynthetic glycosyltransferases cause severe muscular, neurological and cardiac disorders. Despite its biological and clinical importance, the structural basis of mammalian O-Man biosynthesis has remained unknown. Here we report cryo-electron microscopy (cryo-EM) structures of human TMEM260, an endoplasmic...

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Literature Corpus work: 1b0a490d-7b2b-5ab4-8b18-b48a425577b5
DOI: 10.64898/2026.03.17.711096

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