Article

Increased extracellular matrix stiffness regulates myofibroblast transformation through induction of autophagy-mediated Kindlin-2 cytoplasmic translocation

2023-06-26

Abstract excerpt

The extracellular matrix (ECM) provides structural support for connective tissue and environmental cues for cells. Its mechanical properties regulate biological processes, such as fibroblast-myofibroblast transformation (FMT), which is a crucial component in pelvic organ prolapse (POP) development and leads to an increase in ECM stiffness. The ‘Kindlin-2’ protein, expressed by fibroblasts, plays an important role...

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Literature Corpus work: d943a57b-e242-5514-bd5f-b93777ecc226
DOI: 10.21203/rs.3.rs-3067260/v1

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