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Fibronectin sensitizes activation of contractility, YAP, and NF‐κB in nucleus pulposus cells

1 Aug 2023

Abstract excerpt

Intervertebral disc degeneration involves the breakdown of the discs of the spine due to genetics, aging, or faulty mechanical loading. As part of the progression of the disease, nucleus pulposus cells lose their phenotypic characteristics, inducing inflammation and extracellular matrix (ECM) alterations that result in a loss of disc mechanical homeostasis. Fibronectin is one ECM molecule that has been shown to...

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PMID: 37525423
DOI: 10.1002/jor.25670

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