Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced Smoothened level rescues Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease.

Journal of genetics and genomics = Yi chuan xue bao - 20 May 2018

Ma Weiwei, Wu Mengnan, Zhou Siyan, Tao Ye, Xie Zuolei, Zhong Yi

Abstract excerpt

Emerging evidence suggests that neuro-inflammation begins early and drives the pathogenesis of Alzheimer's disease (AD), and anti-inflammatory therapies are under clinical development. However, several anti-inflammatory compounds failed to improve memory in clinical trials, indicating that reducing inflammation alone might not be enough. On the other hand, neuro-inflammation is implicated in a number of mental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition

Share to Disease Models, Animal

Share to Down-Regulation

Share to Memory Disorders

Share to Neurons

Share to Smoothened Receptor

Source

Identifiers

PMID: 29807798
DOI: 10.1016/j.jgg.2018.05.001

Genes

SMO
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced Smoothened level rescues Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease.PMID 29807798Read ↗

Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice.Semantic proximity Read ↗

Maresin-like 1 Ameliorates Neuropathology of Alzheimer's Disease in Brains of a Transgenic Mouse ModelSemantic proximity Read ↗

Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic MiceSemantic proximity Read ↗

The soluble epoxide hydrolase inhibitor TPPU alleviates Aβ-mediated neuroinflammatory responses in Drosophila and cellular models of Alzheimer's diseaseSemantic proximity Read ↗

Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockout miceSemantic proximity Read ↗

All-trans retinoic acid improved impaired proliferation of neural stem cells and suppressed microglial activation in the hippocampus in an Alzheimer's mouse model.Semantic proximity Read ↗

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunctionSemantic proximity Read ↗

Experimental colitis in young Tg2576 mice accelerates the onset of an Alzheimer's-like clinical phenotype.Semantic proximity Read ↗

Microglia Activated with the Toll-Like Receptor 9 Ligand CpG Attenuate Oligomeric Amyloid β Neurotoxicity in in Vitro and in Vivo Models of Alzheimer’s DiseaseSemantic proximity Read ↗

4-O-methylhonokiol prevents memory impairment in the Tg2576 transgenic mice model of Alzheimer's disease via regulation of β-secretase activity.Semantic proximity Read ↗

The Role of S100a9 in the Pathogenesis of Alzheimer’s Disease: The Therapeutic Effects of S100a9 Knockdown or KnockoutSemantic proximity Read ↗

Hypoglycemia Aggravated Cognitive Degeneration by activating Endothelial ZBP1-mediated PANoptosis in Type 2 DiabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.