Article

From Bone Marrow Mutation to Cognitive Deficit: A Strategy for Personalised Correction of CHIP-Associated Neuroinflammation in Cardiac Surgery

2026-07-01

Abstract excerpt

In contemporary cardiac surgery, preservation of cognitive function has become the principal criterion of success; however, postoperative cognitive dysfunction (POCD), documented in 30–80% of patients, negates the benefits of the operation. Traditional risk factors explain only part of the genesis of this deficit. A key link is clonal haematopoiesis of indeterminate potential (CHIP): somatic mutations in haematopo...

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Literature Corpus work: 1ef76747-f811-5111-af30-8011511396a5
DOI: 10.20944/preprints202607.0039.v1

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