Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of fingolimod administration in a genetic model of cognitive deficits.

Journal of neuroscience research - 1 May 2017

Becker-Krail D, Farrand A Q, Boger H A, Lavin A

Abstract excerpt

Notwithstanding recent advances, cognitive impairments are among the most difficult-to-treat symptoms in neuropsychiatric disorders. Deficits in information processing contributing to memory and sociability impairments are found across neuropsychiatric-related disorders. Previously, we have shown that mutations in the DTNBP1 gene (encoding dystrobrevin-binding protein 1 [dysbindin-1]) lead to abnormalities in...

Topics

Join the communities discussing this publication.

Brain-Derived Neurotrophic Factor
Cerebral Cortex
Cognition Disorders
Dysbindin
Immunosuppressive Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Social Behavior

Source

Open in PubMed Open full text

Identifiers

PMID: 27439747
DOI: 10.1002/jnr.23799
PMCID: PMC6636312

Genes

BDNF
DTNBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of fingolimod administration in a genetic model of cognitive deficits.PMID 27439747Read ↗

Cognition Enhancement Strategies: Figure 1.Semantic proximity Read ↗

Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse modelSemantic proximity Read ↗

Optimizing Fingolimod Dosing in STZ-Induced Cognitive Impairment: Divergent Behavioral and Histopathological Responses Reveal a Narrow Neuroprotective WindowSemantic proximity Read ↗

Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy.Semantic proximity Read ↗

Cognitive Phenotypes for Biomarker Identification in Mental Illness: Forward and Reverse Translation.Semantic proximity Read ↗

Potential molecular mechanisms for decreased synaptic glutamate release in dysbindin-1 mutant mice.Semantic proximity Read ↗

Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of Phosphodiesterase 2ASemantic proximity Read ↗

Neuroinflammation underlies the development of social stress induced cognitive deficit in sickle cell diseaseSemantic proximity Read ↗

Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's DiseaseSemantic proximity Read ↗

Single point mutation on the gene encoding dysbindin results in recognition deficits.Semantic proximity Read ↗

Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia.Semantic proximity Read ↗

Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.