Article

An aberrant protamine ratio is associated with decreased H4ac levels in murine and human sperm

2024-08-11

Abstract excerpt

<h4>ABSTRACT</h4> Protamine 2 ( Prm2/PRM2 ), together with Protamine 1 ( Prm1/PRM1 ), constitute the two protamines found in both murine and human sperm. During spermiogenesis in haploid male germ cells, chromatin undergoes significant condensation, a phase in which most histones are replaced by a species-specific ratio of these two protamines. Altered PRM1/PRM2 ratios are associated with subfertility and infer...

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Literature Corpus work: d938c261-e85b-57ff-b2d4-93c56216621a
DOI: 10.1101/2024.08.11.606797

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