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Article

<i>Prm2</i> deficiency triggers a Reactive Oxygen Species (ROS)-mediated destruction cascade during epididymal sperm maturation in mice

2020-05-05

Abstract excerpt

Protamines are the safeguards of the paternal sperm genome. They replace most of the histones during spermiogenesis, resulting in DNA hypercondensation, thereby protecting its genome from environmental noxa. Impaired protamination has been linked to male infertility in mice and humans in many studies. Apart from impaired DNA integrity, protamine-deficient human and murine sperm show multiple secondary effects, inc...

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Literature Corpus work
21286647-74a3-593c-b00f-d350f864a251
DOI
10.1101/2020.05.05.075929
Open publication

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<i>Prm2</i> deficiency triggers a Reactive Oxygen Species (ROS)-mediated destruction cascade during epididymal sperm maturation in miceDOI 10.1101/2020.05.05.075929
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