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Article

The Clinical Utility of the Protamine 1/Protamine 2 Ratio in Sperm

1 Aug 2011

Abstract excerpt

During spermiogenesis, human sperm undergo a dramatic reorganization of the chromatin in which canonical histones are replaced by two types of protamines, protamine 1 (P1) and protamine (P2). P1 and P2 are expressed approximately at a 1:1 ratio in healthy men. Alteration of this ratio is associated with male infertility. Patients with an abnormal P1/P2 ratio generally exhibit diminished semen quality, lower...

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PMID: 21443494
DOI: 10.2174/092986611795713934

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