Article

Enhanced replication of mouse adenovirus type 1 following virus-induced degradation of protein kinase R (PKR)

2019-03-21

Abstract excerpt

Protein kinase R (PKR) plays a major role in activating host immunity during infection by sensing dsRNA produced by viruses. Once activated by dsRNA, PKR phosphorylates the translation factor eIF2α, halting cellular translation. Many viruses have methods of inhibiting PKR activation or its downstream effects, circumventing protein synthesis shutdown. These include sequestering dsRNA or producing proteins that bind...

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Literature Corpus work: d9316451-8516-513f-baae-20f70d9d336f
DOI: 10.1101/584680

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