Article
The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response.
PLoS pathogens - 1 Feb 2016
Brestovitsky Anna, Nebenzahl-Sharon Keren, Kechker Peter, Sharf Rakefet, Kleinberger Tamar
Abstract excerpt
The DNA damage response (DDR) is a conglomerate of pathways designed to detect DNA damage and signal its presence to cell cycle checkpoints and to the repair machinery, allowing the cell to pause and mend the damage, or if the damage is too severe, to trigger apoptosis or senescence. Various DDR branches are regulated by kinases of the phosphatidylinositol 3-kinase-like protein kinase family, including...
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