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Article

PKR Transduces MDA5-Dependent Signals for Type I IFN Induction.

PLoS pathogens - 1 Mar 2016

Pham Alissa M, Santa Maria Felicia Gilfoy, Lahiri Tanaya, Friedman Eugene, Marié Isabelle J, Levy David E

Abstract excerpt

Sensing invading pathogens early in infection is critical for establishing host defense. Two cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) induction in response to viral infection. Mounting evidence suggests that another viral RNA sensor, protein kinase R (PKR), may also be critical for IFN induction during infection, although its exact contribution and mechanism of action...

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Share to DEAD Box Protein 58
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Interferon-Induced Helicase, IFIH1

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Source

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Identifiers

PMID: 26939124
DOI: 10.1371/journal.ppat.1005489
PMCID: PMC4777437

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MAVS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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