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Article

Activation of the Antiviral Kinase PKR and Viral Countermeasures

27 Oct 2009

Abstract excerpt

The interferon-induced double-stranded (ds)RNA-dependent protein kinase (PKR) limits viral replication by an eIF2α-mediated block of translation. Although many negative-strand RNA viruses activate PKR, the responsible RNAs have long remained elusive, as dsRNA, the canonical activator of PKR, has not been detected in cells infected with such viruses. In this review we focus on the activating RNA molecules of...

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PMID: 21994559
DOI: 10.3390/v1030523

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