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Activation of protein kinase receptor (PKR) plays a pro-viral role in mammarenavirus-infected cells

20 Feb 2024

Abstract excerpt

Many viruses, including mammarenaviruses, have evolved mechanisms to counteract different components of the host cell innate immunity, which is required to facilitate robust virus multiplication. The double-stranded RNA (dsRNA) sensor protein kinase receptor (PKR) pathway plays a critical role in the cell anti-viral response. Whether PKR can restrict the multiplication of the Old World mammarenavirus lymphocytic...

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PMID: 38376197
DOI: 10.1128/jvi.01883-23

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