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PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response

18 May 2009

Abstract excerpt

The double-stranded RNA-activated protein kinase (PKR) is a key regulator of protein translation, interferon (IFN) expression and cell survival. Upon infection of vertebrate cells in continuous culture, the alphavirus Semliki Forest virus (SFV) initiates apoptosis and IFN synthesis. To determine the effect of PKR on SFV infection, we studied the course of infection in wild-type (wt) mice, mice with a genetic...

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PMID: 19264662
DOI: 10.1099/vir.0.007336-0

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