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Article

HORMAD1 Polymorphisms Influence Susceptibility to Esophageal Squamous Cell Carcinoma Through Gene-Smoking Interaction.

Molecular carcinogenesis - 1 Nov 2025

Yue Xinying, Yang Zifei, Ma Jialing, Su Qianqian, Pan Miaoxin, Song Lina, Li Yueping, Liu Shasha, Wu Yutong, Chang Jiang

Abstract excerpt

Tobacco smoke is a major risk factor for esophageal squamous cell carcinoma (ESCC), yet only a subset of smokers develop this disease, implicating gene-smoking interactions in modulating individual susceptibility. Through integrative transcriptomic analyses of normal and tumor samples from smokers and nonsmokers, we identify four smoke-responsive genes (CXCL14, HORMAD1, WFDC5, and MPZ) as potential contributors...

Read the complete abstract on PubMed

Topics

Humans
Esophageal Squamous Cell Carcinoma
Esophageal Neoplasms
Male
Genetic Predisposition to Disease
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Case-Control Studies

Smoking

Middle Aged

Polymorphism, Single Nucleotide

Gene Expression Regulation, Neoplastic

Cell Cycle Proteins

Cell Line, Tumor

Source

Identifiers

PMID: 40875139
DOI: 10.1002/mc.70039

Genes

HORMAD1
CXCL14
HOXA6
MPZ
SOX15
WFDC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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