Article

TRMT10A deficiency and tRNA fragmentation disrupt human pancreatic β-cell identity and insulin maturation

2026-07-23

Abstract excerpt

Mutations in the tRNA-modifying enzyme TRMT10A cause a rare monogenic syndrome characterized by early-onset diabetes and neurodevelopmental defects, yet the molecular mechanisms underlying TRMT10A diabetes remain unclear. Using human TRMT10A -deficient (knockout and mutant) induced pluripotent stem cells (iPSCs) differentiated into islet-like aggregates and TRMT10A -silenced EndoC-βH1 human β-cells, we show tha...

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Literature Corpus work: 3e2d7935-f1c5-5414-9145-a184a6a8275e
DOI: 10.64898/2026.07.22.739528

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