Article

A Scalable, Open-Source Implementation of a Large-Scale Mechanistic Model for Single Cell Proliferation and Death Signaling

2020-11-10

Abstract excerpt

<h4>ABSTRACT</h4> Mechanistic models of how single cells respond to different perturbagens can help integrate disparate big data sets or predict response to varied drug combinations. However, the construction and simulation of such models have proved challenging. Our lab previously constructed one of the largest mechanistic models for single mammalian cell regulation of proliferation and death (774 species, 141 g...

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Literature Corpus work: d5762eee-aed8-5928-9fac-a0253e4092da
DOI: 10.1101/2020.11.09.373407

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