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Article

Primary myelofibrosis and the "bad seeds in bad soil" concept

6 Jun 2012

Abstract excerpt

Primary Myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by a clonal myeloproliferation and a myelofibrosis. The concomitant presence of neoangiogenesis and osteosclerosis suggests a deregulation of medullar stem cell niches in which hematopoietic stem cells are engaged in a constant crosstalk with their stromal environment. Despite the recently discovered mutations including the...

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PMID: 23259918
DOI: 10.1186/1755-1536-5-s1-s20

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