Article

SGLT2 Inhibition Induces Autophagic Flux Blockade and Sensitizes Pancreatic Cancer to EGFR-Targeted Therapy

2026-02-26

Abstract excerpt

<title>Abstract</title> <p>Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with profound metabolic rewiring and resistance to therapy. Sodium-glucose co-transporter 2 (SGLT2) regulates glucose uptake, but its role in PDAC remains unclear. Methods SGLT2 expression was analyzed in clinical samples and public datasets. PDAC cell lines were subjected to genetic knockdown or canagliflozin (...

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Literature Corpus work: d8d49e5c-b336-58ea-ae47-540fbd4a48c1
DOI: 10.21203/rs.3.rs-8820380/v1

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