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Mechanistic insights and therapeutic strategies for targeting autophagy in pancreatic ductal adenocarcinoma

23 Apr 2025

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is characterised by early metastasis and resistance to anti-cancer therapy, leading to an overall poor prognosis. Macroautophagy (hereinafter referred to as autophagy) is a conserved cellular homeostasis mechanism that degrades various cargoes (e.g., proteins, organelles, and pathogens) mainly playing a role in promoting survival under environmental stress. Autophagy is an...

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PMID: 40266451
DOI: 10.1007/s12672-025-02400-x

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