Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KRAS: feeding pancreatic cancer proliferation.

Trends in biochemical sciences - 1 Feb 2014

Bryant Kirsten L, Mancias Joseph D, Kimmelman Alec C, Der Channing J

Abstract excerpt

Oncogenic KRAS mutation is the signature genetic event in the progression and growth of pancreatic ductal adenocarcinoma (PDAC), an almost universally fatal disease. Although it has been appreciated for some time that nearly 95% of PDAC harbor mutationally activated KRAS, to date no effective treatments that target this mutant protein have reached the clinic. A number of studies have shown that oncogenic KRAS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ras Proteins
Share to Autophagy
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose

Share to Glutamine

Share to Isoenzymes

Share to Pancreatic Neoplasms

Share to Pinocytosis

Source

Open in PubMed Open full text

Identifiers

PMID: 24388967
DOI: 10.1016/j.tibs.2013.12.004
PMCID: PMC3955735

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KRAS: feeding pancreatic cancer proliferation.PMID 24388967Read ↗

Oncogenic KRAS triggers metabolic reprogramming in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Interplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective TreatmentSemantic proximity Read ↗

The complex landscape of pancreatic cancer metabolismSemantic proximity Read ↗

KRAS mutation: The booster of pancreatic ductal adenocarcinoma transformation and progressionSemantic proximity Read ↗

Conceptual Framework for Cutting the Pancreatic Cancer Fuel SupplySemantic proximity Read ↗

Oncogenic KRAS signalling in pancreatic cancerSemantic proximity Read ↗

Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets.Semantic proximity Read ↗

Targeting KRAS: from metabolic regulation to cancer treatmentSemantic proximity Read ↗

Simultaneous inhibition of PFKFB3 and GLS1 selectively kills KRAS-transformed pancreatic cells.Semantic proximity Read ↗

Pancreatic Cancer Metabolism: Breaking It Down to Build It Back UpSemantic proximity Read ↗

Cellular metabolism in pancreatic cancer as a tool for prognosis and treatment (Review)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.