Article
Glutamine-restricted diets restore sensitivity to KRASG12D inhibitor through the reversal of ANXA1 mediated metabolic reprogramming.
Cell reports. Medicine - 18 Aug 2026
Li Jiatong, Gu Ao, Jia Ziheng, Li Mengyao, Zuo Jinlu, Wang Ziyi, Li Xuechuan, Feng Jiayi, Xue Tong, Zhai Shuyang, Yue Zhuying, An Yang, Kang Siyuan, Yuan Zhiqing, Qiu Shimei, Xue Yadong, Liu Liguo, Tang Nannan, Liu Yingbin
Abstract excerpt
Approximately 90% of patients with pancreatic cancer harbor KRAS mutations, predominantly the KRASG12D subtype. HRS-4642, a non-covalent inhibitor targeting KRASG12D, demonstrates potent antitumor efficacy but may ultimately lead to resistance. This study investigates the mechanisms underlying KRASG12D inhibitor resistance and evaluates strategies to enhance treatment sensitivity. Our findings indicate that a...
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