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Article

Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose Transport.

Molecular cell - 17 Aug 2017

Nagarajan Arvindhan, Dogra Shaillay Kumar, Sun Lisha, Gandotra Neeru, Ho Thuy, Cai Guoping, Cline Gary, Kumar Priti, Cowles Robert A, Wajapeyee Narendra

Abstract excerpt

Metabolic deregulation is a hallmark of human cancers, and the glycolytic and glutamine metabolism pathways were shown to be deregulated in pancreatic ductal adenocarcinoma (PDAC). To identify new metabolic regulators of PDAC tumor growth and metastasis, we systematically knocked down metabolic genes that were overexpressed in human PDAC tumor samples using short hairpin RNAs. We found that p53 transcriptionally...

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Source

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Identifiers

PMID: 28803777
DOI: 10.1016/j.molcel.2017.07.014
PMCID: PMC5567863

Genes

PON2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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