Article

LncRNA YIYA enhances pancreatic cancer proliferation under high-glucose conditions through RAS–PKM2–mediated metabolic reprogramming that reinforces the Warburg phenotype

2025-10-31

Abstract excerpt

Diabetes and the resulting hyperglycemia are metabolic complications frequently linked to pancreatic cancer (PC). In this study, we observe that the long non-coding RNA (lncRNA)-YIYA, which resides in a genomic region (1q32), frequently altered in various cancers, is overexpressed under conditions of chronic or intermittent high glucose (HG; 25 mM) compared to normal glucose (NG; 5.5 mM) in pancreatic ductal adeno...

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Literature Corpus work: df865cdb-14fb-5984-b586-e0b0333fa0ad
DOI: 10.1101/2025.10.30.685546

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