The ageing epigenome: damaged beyond repair?

Abstract excerpt

Of all the proposed causes of ageing, DNA damage remains a leading, though still debated theory. Unlike most other types of age-related cellular damage, which can hypothetically be reversed, mutations in DNA are permanent. Such errors result in the accumulation of changes to RNA and protein sequences with age, and are tightly linked to cellular senescence and overall organ dysfunction. Over the past few years, an...

Topics

• Aging
• Animals
• Cellular Senescence
• Chromatin
• DNA Damage
• DNA Repair
• Epigenesis, Genetic
• Genomic Instability
• Humans
• Mutation
• Oxidative Stress
• Protein Processing, Post-Translational