Article

The balance between toxic versus nontoxic microRNAs determines platinum sensitivity in ovarian cancer

2021-01-26

Abstract excerpt

<h4>ABSTRACT</h4> Numerous micro(mi)RNAs (short noncoding RNAs that negatively regulate gene expression) have been linked to platinum (Pt) sensitivity and resistance in ovarian cancer (OC). miRNA activity occurs when the guide strand of the miRNA, with its seed sequence (pos. 2-7/8), is loaded into the RNA induced silencing complex (RISC) and targets complementary short seed matches in the 3’ untranslated region...

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Literature Corpus work: 6769377b-dc72-54d8-8c83-b1f16eb22f7e
DOI: 10.1101/2021.01.24.427815

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