Article

6mer seed toxicity in viral microRNAs

2019-11-12

Abstract excerpt

<h4>SUMMARY</h4> Micro(mi)RNAs are short double stranded noncoding RNAs (19-23nts) that regulate gene expression by suppressing mRNAs through RNA interference. Targeting is determined by the seed sequence (position 2-7/8) of the mature miRNA. A minimal G-rich seed of just 6 nucleotides is highly toxic to cells by targeting genes essential for cell survival. A screen of 215 miRNAs encoded by 17 human pathogenic vi...

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Literature Corpus work: 0a42a5cd-850a-52e0-b7b4-ac991079170a
DOI: 10.1101/838979

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