Article

Systematic optimization of siRNA productive uptake into resting and activated T cells <i>ex vivo</i>

2023-10-20

Abstract excerpt

RNA-based medicines are ideally suited for precise modulation of T cell phenotypes in anti-cancer immunity, in autoimmune diseases and for ex vivo modulation of T-cell-based therapies. Therefore, understanding productive siRNA uptake to T cells is of particular importance. Most studies used unmodified siRNAs or commercially available siRNA with undisclosed chemical modifications patterns to show functionality in...

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Literature Corpus work: d88df8d9-80ef-5a16-b4a4-06a37d0bcc4c
DOI: 10.1101/2023.10.20.563275

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